Nortriptyline Facts: Dosages, Overdose & Side Effects

Explore the various dosages of Nortriptyline Hydrochloride Apart from that this article goes further to highlight what constitutes an overdose and the associated side effects of Nortriptyline.

What is 10mg and 25mg Nortriptyline used for? Well, all these have been answered here.

What is Nortriptyline HCl?

Nortriptyline Hydrochloride belongs to the group of tricyclic antidepressants. It is commonly sold under different brand names including Aventyl, Allegron, Nortilen, Pamelor, and Noritren, among others.

It is primarily licensed to cure clinical depression but can be applied for other purposes up to including the treatment of infantile bedwetting.

This medication is a metabolite of amitriptyline and can treat various forms of depression, such as dysthymia, major, and atypical depressions. Its primary mechanism of action is by hindering the norepinephrine receptors.

By doing that, inhibits the reuptake of this vital neurotransmitter and elevating its concentration in the synaptic cleft in the Central Nervous System (CNS).

Its other mechanism of action is through the active binding to the histaminergic, alpha-adrenergic, and cholinergic receptors, hence hindering the active activities of these receptors.

If you take the drug for a long time, it results in the downregulation of adrenergic receptors because of the elevated stimulation of these receptors.

It is a water-soluble drug, which means you can decide to dissolve it using water before taking it.

Also, it implies that it is not harmful for human consumption because it can readily dissolve with water once it is in the stomach, especially if you take its tablet form.

When the drug is heated, it usually emits poisonous fumes of nitrogen oxide. Therefore, it is recommended that you keep the drug in a secure area, far from heat and reach by children.

Only remove them from their storage locations when you want to take them as prescribed by the doctor. Store the drug at 20 to 25 °C.

Active Components in Nortriptyline

This antidepressant consists of numerous elements that make it effective in treating various human ailments.  These components are:

  1. Those that are inactive when the route of administration is oral- magnesium stearate, sodium lauryl sulfate, pregelatinized starch, and colloidal silicon dioxide.
  2. The 10, 25, 50, and 75mg tablet shells contain- Methylparaben, titanium dioxide, sodium lauryl sulfate, gelatin, and Propylparaben.
  3. The shells of the 10,25 and 75 mg tablets contain FD & C Blue number one and D & C Yellow number ten.
  4. Other components that this drug may contain are edetate calcium disodium, sodium propionate, benzyl alcohol, silicon dioxide, and Butylparaben.

What is Nortriptyline 10mg & 25mg Used For?

The 10mg Nortriptyline is usually found in every capsule that has a yellow opaque cap and white opaque body with an ‘AVETYL H17′ written on both sides.

The 25 mg, on the other hand, is found in every tablet that has a body and cap the same as that of 10mg but on its sides, it is written ‘AVENTYL H19′.

These dosages are usually taken to boost an individual’s mood, which directly aids in the relief from depression.

However, the quantity for adults and children do differ. In particular, the starting dosage for adults is usually 25mg, while in special cases for children, it is 10mg.

The adults are required to take their 25mg dosage at least two times a day, but not more than four times.

However, the number of times a person should consume the drug should only be given by a professional doctor to prevent overdose that can have severe consequences.

Similarly, the drugs can be administered to young children who are bedwetting.

The drug has been studied, and findings indicate that when a child uses the drug, the rate of bedwetting reduces, and he or she can eventually stop bedwetting.

However, that can only happen when the parent administers the right dosage (10mg) to the child twice every day.

Nortriptyline Brand Names

Being aware of the various brand names, this antidepressant is known across the globe is important.

It is vital because it will help you identify genuine drugs, especially when an unlicensed individual wants to sell you the drugs across the streets.

I know you are asking why does this drug has several brand names.

Well, the names are several because each time there is an upgrade on the drug, which has been tested and proven by the drug controller to be effective, that drug must be given a new name to differentiate it from the initial ones.

About Nortriptyline, the drug has several names including the famously known Aventyl, Allegron, Nortilen, Pamelor and Noritren.

However, there are other names, which are usually given by a particular company that manufactured that drug.

For instance, the following are the other brand names with their respective manufacturers.

  1. Deprival 25 – manufactured by Psycho Remedies and is in tablet form.
  2. Sensival – by Wallace Pharmaceuticals.
  3. Sensaril – by Reliance Formulation Company.
  4. Trip – by PIFER Pharmaceutical Company.
  5. Nortin – by La Pharmaceuticals.
  6. Primox – by Sun Pharmaceutical industries

Note:  These are not the only brand names. There several others and every country may have different brand names. Therefore, to avoid purchasing fake products, you are advised to buy nortriptyline medicines from a government registered pharmacy or health center.

Uses of Nortriptyline HCl

Nortriptyline has numerous uses because it can be applied to relieve you from all kinds of pain and depression. Nevertheless, the following are the man application of this drug:


Application as an antidepressant is the main licensed application of this drug.

It is administered to a person to relieve him or her from the symptoms of this condition, such as irritability, sleeplessness, sadness, and loss of interest.

The drug treats the condition by increasing the level of norepinephrine, an important neurotransmitter found in your brain.

When you are suffering from depression, all you need to do is to visit a healthcare giver, who will tell you the precise dosage you need to take to heal from that condition.


When you take Nortriptyline and experience an increased incidence of heartburn, you should not worry.

The drug, together with other tricyclic antidepressants such as imipramine and amitriptyline, has been discovered to cause acid reflux that increases heartburn.

Therefore, the best way to treat the condition is to reduce the dosage of Nortriptyline. However, before you do that, make sure you consult your doctor, he or she may be having a different solution to your problem.

Hair loss

Hair loss is one of the rare side effects of Nortriptyline. When you notice that you are developing that problem and you are under this medication, you should reduce the dosage.

In particular, if you were taking 25mg Nortriptyline three times a day, you can start taking it twice a day.

If the problem, persists you should consult the medical doctor immediately. The doctor will give further instructions on what to do to treat hair loss.


While the drug is not primarily meant to treat headaches, it has been discovered to have a magnificent effect in lowering headaches in individuals suffering from depression.

A clear indication that the drug has a double benefit- treating depression and headaches at the same time!

Similarly, in individuals who are not suffering from depression but are experiencing headaches, the drug can be used to cure it.

However, the individual is required to adhere to the prescriptions given by a healthcare expert to avoid generating other healthcare problems associated with the abuse of this antidepressant.

Nerve pain

Nerve pain can be quite disturbing, and sometimes when it gets severe, an individual may fail to attend to his or her normal daily activities.  Usually, the 10mg prescription is the one that is applied when treating nerve pain.

If the pain persists even after taking this drug as prescribed, you are advised to stop using it immediately and report to your doctor.

Nortriptyline Dosages

The prescriptions of this antidepressant are usually given based on the age of an individual. In particular, for adults, the required amount to take is 25 mg three to four times in a single day.

On the other hand, for individuals who are under 18 years, the recommended drug dosages are 35 to 50 mg once a day or subdivide into doses.

Note that strict adherence to the doctor’s prescriptions is mandatory to avoid taking the drug in overdose or underdose, which may generate other severe health complications.

Nortriptyline Overdose – Symptoms & Treatment

Taking Nortriptyline above what you are required to take is extremely life-threatening. You can tell that you or your friend or a family member has taken an overdose of this drug if the following symptoms are available.

  1. Blurred vision
  2. Muscle stiffness
  3. Feeling cold or hot
  4. Coma
  5. Seizure
  6. Extreme confusion
  7. Agitation
  8. Hallucinations
  9. Increased vomiting
  10. Extreme drowsiness

When you note these symptoms, the first thing you should do is contact the caregiver. The caregiver will then examine the seriousness of the condition and give you the treatments.

The most common medications are sodium bicarbonate, activated charcoal, and gastric lavage, which can lower the absorption rate of this drug.

Nortriptyline HCl Side Effects

Indeed, just like any other medication, Nortriptyline has side effects on individuals after being used for some time. The drug can have short-term or long-term effects.

Nortriptyline long term side effects include dry mouth, dizziness, rapid palpitations, tremor, headache, blurred vision, weight gain, and sweating.

The short-term effects, which again are not common, include sexual problems like lowered sex drive, tiredness, hair loss, difficulties passing urine.

Regardless, an individual is expected to report these problems to the healthcare giver to receive earlier medication before the symptoms associated with the side effects worsen.

Nortriptyline and Alcohol

Individuals who like drinking alcohol are usually advised to stop taking alcohol during the periods they will be taking this medication.

The reason for that is that when you take alcohol, you increase the sedative effects of this antidepressant.  This may make you dizzy, drowsy, and sleepier and if this happens, you should not drive.

Nortriptyline Reviews

Across all the social media sites, you can never fail to find two or more reviews about the application and effectiveness of this antidepressant.

Usually, the reviews are either positive or negative depending on the effects the drug had on the reviewer.

Here are some of the reviews

‘Taking this drug Nortriptyline for nerve pain and spinal compression pain. The pain has diminished since the start of taking this drug.’

‘Since I started taking Nortriptyline for headaches and depression, I am now well and I can recommend it to my friends suffering from the same.’

‘The much-praised Nortriptyline never worked for me when I was suffering severe nerve pain. I cannot advise my friend to use it.’

The above reviews are a clear indication that different people have different opinions regarding the use of Nortriptyline.

However, most people prefer the drug, and the few who do not like it maybe did not adhere to the prescriptions, hence the reason why it failed to work.

References on Nortriptyline Overdose Side Effects

  • Canoe: Aventyl Uses, Side Effects, Interactions
  • PubChem: Nortriptyline Hydrochloride – C19H22ClN
  • RxList: Nortriptyline Hydrochloride Capsules

READ MORE: Nortriptyline dosage for neuropathy

Check Also

Amitriptyline Dosage for Migraines & Headaches

Learn the recommended doses for using amitriptyline for persistent headaches and migraines. Apart from the …